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Toxicity

A prospective study of 51 pediatric patients at a poison-control center proposed that less than 250 mg/kg of amoxicillin overdosages are not associated with significant clinical symptoms(Product labeling FDA).

Clinical Features

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Overdose

Symptoms: gastrointestinal symptoms and water-electrolyte imbalance may occur. Amoxicillin crystalluria is described, in some cases leading to the development of renal failure. Convulsions may occur in patients with impaired renal function, as well as in those who receive high doses of the drug.

Treatment: gastrointestinal symptoms - symptomatic therapy, paying particular attention to normalizing the water-electrolyte balance. In case of an overdose, amoxicillin and clavulanic acid can be removed from the bloodstream by hemodialysis.