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What Vistamethasone Drops are The active ingredient is betamethasone sodium phosphate 0.1% w / v The other ingredients are benzalkonium chloride solution, disodium edetate, sodium phosphate and purified water What Vistamethasone Drops look like and contents of the pack Vistamethasone Drops are a clear, colorless sterile solution supplied in a plastic bottle with a cap. Each bottle contains 5 or 10ml of the solution. Marketing Authorization Holder: Martindale Pharmaceuticals Ltd. Bampton Road Harold Hill Romford RM3 8UG United Kingdom Manufacturers: Martindale Pharmaceuticals Bampton Road Harold Romford Hill RM3 8UG Farmigea SpA Via GB Oliva 6/8 56121 Pisa, Italy If you would like any more information, or would like the leaflet in a different format, please contact Medical Information at the above address. This leaflet was last updated in September 2012 Product License Number: PL 00156/0083 .

1. What are Vistamethasone Drops? What are they used for? Vistamethasone Drops 3. How to use Vistamethasone Drops 4. Possible side effects 5. How to store Vistamethasone Drops 6. Further information.

4. Possible side effects Like all medicines, Vistamethasone N Drops can cause side effects, not everybody gets them. Possible side effects include: • irritation, burning, itching and stinging in the area. This may occur after treatment has stopped. • raised pressure in the eye (only when used in the eye) which may damage the optic nerve for poor vision. Vistamethasone N Drops, which causes a thinning of the surface of the eye, serious damage may be caused. Prolonged use of this medicine can lead to the cloudiness of the lens of the eye (cataracts); It is therefore that the lens of the eye is checked frequently during this medicine. If any of the side effects get serious, please tell your doctor or pharmacist.

3. How to use Vistamethasone N Drops Always use Vistamethsone N Drops exactly as your doctor has told you. You should check with your doctor or pharmacist if you are not sure. How much to use? For adults, the elderly and children For the use of the eye: The usual starting dose is one or two drops. Your doctor may reduce the dose of your eye. For use in the ear: The usual starting dose is two or three drops. Your doctor can reduce the dose of your condition. For use in the nose: The usual dose is two or three drops in each nostril twice daily as required. Instructions for use in the eye If you wear contact lenses they must be removed before treatment with Vistamethasone N Drops. 1. Before opening a new bottle of Vistamethasone N Drops, please check that the safety strip on the bottom of the outer cap is unbroken. 2. Twist the outer cap to break the seal. 3. Wash your hands well before use. 4. Remove the outer cap. If you are putting in the drops you should use a mirror. 5. Tilt your head back and look up at the ceiling. Continued overleaf.

Betamethasone Sodium Phosphate 0.1% w / v Neomycin Sulphate 0.5% w / v Read all of this leaflet It contains important information. • Keep this leaflet. You may need to read it again. • If you have any further questions, ask your doctor or pharmacist. • This medicine has been prescribed for you. Do not pass it on to others. It can harm them, even if their symptoms are the same as yours. • If any of the side effects gets serious, please tell your doctor or pharmacist.

In this leaflet: 1. What Vistamethasone N Drops and How They Are Used for 2. Before You Use Vistamethasone N Drops 3. How to use Vistamethasone N Drops 4. Possible side effects 5. How to store Vistamethasone N Drops 6. Further information.

Nasal administration of corticosteroids is not advised if an untreated nasal infection is present, or if the patient has pulmonary tuberculosis or following nasal surgery.

If you have ever had an allergic reaction to a medicine. If you think you have an infection in your nose. If you have had any surgery on your nose. If you have tuberculosis (TB) in your lungs. If you are pregnant or breastfeeding.

You can get a slight feeling of irritation or dryness. This is usually mild and soon passes. If you develop a skin rash or if you notice any other symptoms.

If you are having an operation or any medical treatment, tell the person carrying out the treatment which you are taking.

Indications / Uses: Severe inflammatory skin disorders (eczema, psoriasis, dermatitis); cream or anointed 0.1%. orally for allergic and inflammatory conditions.

Never use the drops for more than seven days unless your doctor has asked you to. If your symptoms have not been improved after seven days of treatment, you should stop using the drops and see your doctor. If your doctor is looking for a cure, you should have regular check-ups.

Do not wear contact lenses while using betamethasone drops in your eyes because they may make your eye inflammation worse. The drops contain a preservative called benzalkonium chloride, which can be absorbed by contact lenses and cause eye irritation.

It's important to tell you what you're about, and you're starting to use it, before you start using betamethasone drops. Similarly, check with your pharmacist before using any new medicines with these drops, to make sure that the combination is safe.

If you suspect that someone has swallowed some of this medicine, go to the accident and emergency department of your local hospital. Take the container with you, even if it is empty.

You can get a slight feeling of irritation or burning. This is usually mild and soon passes. If you get a skin or if you notice any other symptoms.

Common uses: Vista-Methasone (Betamethasone) is a corticosteroid used to treat severe allergies, arthritis, asthma, and skin conditions. A doctor may prescribe Vista-Methasone (Betamethasone) for additional conditions. Read more on Vista-Methasone.

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Common uses: Vista-Methasone (Betamethasone) is a corticosteroid used to treat severe allergies, arthritis, asthma, and skin conditions. A doctor may prescribe Vista-Methasone (Betamethasone) for additional conditions. Read more on Vista-Methasone.

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Allergic Reactions Anaphylactoid reaction, anaphylaxis, angioedema. Cardiovascular Bradycardia, cardiac arrest, cardiac arrhythmias, cardiac enlargement, circulatory collapse, congestive heart failure, fat embolism, hypertension, hypertrophic cardiomyopathy in premature infants, myocardial rupture following recent myocardial infarction, pulmonary edema, syncope, tachycardolism throm. Dermatologic Acne, allergic dermatitis, cutaneous and subcutaneous atrophy, dry scaly skin, ecchymosis and petechiae, edema, erythema, hyperpigmentation, hypopigmentation, uneven wound healing, increased sweating, rash, sterile abscess, striae, suppressed reactions to skin tests, thin fragile skin , thinning scalp hair, urticaria. Endocrine Decreased carbohydrate and glucose tolerance, glucosuria, hirsutism, hypertrichosis, increased requirements for oral insulin or hypoglycemic adrenocortical and pituitary unresponsiveness (particularly in times of stress, pediatric patients. Fluid and Electrolyte Disturbances Congestive heart failure in susceptible patients, fluid retention, hypokalemic alkalosis, potassium loss, sodium retention. Gastrointestinal Abdominal Distention, bowel / bladder dysfunction (after intrathecal administration), elevation in serum liver enzyme levels (usually reversible upon discontinuation), hepatomegaly, increased appetite, nausea, pancreatitis, peptic ulcer with possible perforation and hemorrhage, perforation of the small and large intestine (particularly in patients with inflammatory bowel disease), ulcerative esophagitis. Metabolic Negative nitrogen balance due to protein catabolism. Musculoskeletal Aseptic necrosis of femoral and humeral heads, calcinosis (following intra-articular or intralesional use), Charcot-like arthropathy, loss of muscle mass, muscle weakness, osteoporosis, pathologic fracture of long bones, postinjection flare (following intra-articular use) , steroid myopathy, tendon rupture, vertebral compression fractures. Neurologic / Psychiatric Seizures, depression, emotional instability, euphoria, headache, increased intracranial pressure with papilledema (pseudotumor cerebri) usually following discontinuation of treatment, insomnia, mood swings, neuritis, neuropathy, paresthesia, personality changes, psychic disorders, vertigo. Arachnoiditis, meningitis, paraparesis / paraplegia, and sensory disturbances have occurred after intrathecal administration. Ophthalmic Exophthalmos, glaucoma, increased intraocular pressure, posterior subcapsular cataracts, rare instances of blindness associated with periocular injections. Abnormal fat deposits, increased resistance to infection, hiccups, increased or decreased motility and number of spermatozoa, malaise, moon face, weight gain.

Injectable Suspension is contraindicated in patients who are hypersensitive to any components of this product. Intramuscular corticosteroid preparations are contraindicated for idiopathic thrombocytopenic purpura.

Concurrent use of Phenobarbital, Phenytoin, rifampin or ephedrine can enhance the metabolism of corticosteroids, reducing their therapeutic effects. Patients receiving both corticosteroid and estrogen should be observed for excessive corticosteroid effects. Concomitant use of corticosteroids with potassium-depleting diuretics may enhance hypokalemia with cardiac glycosides may enhance the possibility of arrhythmias or digitalis toxicity associated with hypokalemia. Corticosteroids may enhance the potassium depletion caused by amphotericin B. In all patients of these drug-therapy combinations, serum electrolyte determinations, particularly potassium levels should be closely monitored. Concurrent use of corticosteroids with coumarin-type anticoagulants can increase or decrease the anticoagulant effects. Combined effects of non-steroidal anti-inflammatory drugs or alcohol with glucocorticosteroids may result in an increased occurrence or increased severity of gastrointestinal ulceration. Corticosteroids can decrease blood salicylate concentration. Acetylsalicylic acid should be used cautiously in conjunction with corticosteroids in hypoprothrombinemia. Adjustments of an antidiabetic drug may be necessary when corticosteroids are given to diabetics. Concomitant glucocorticosteroid therapy may inhibit the response to somatotropin. Laboratory test interactions: corticosteroids can affect the nitroblue tetrazolium test for bacterial infection and produce false negative results.